Why prednisone with chemotherapy

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Visibility Others can see my Clipboard. They exert a wide array of effects including effects on the metabolism of carbohydrates, protein and fats. They help to maintain balance of fluids and electrolytes.

Prednisone is classified as a corticosteroid more precisely a glucocorticosteroid , and has many uses in the treatment of cancer. One way that it works is to decrease inflammation swelling. It does this by preventing infection- fighting white blood cells polymorphonuclear leukocytes from traveling to the area of swelling in your body.

This is why you are more prone to infection while taking steroids. Taking advantage of the anti-inflammatory properties of the medication, corticosteroids are used to decrease the swelling around tumors.

For example, by decreasing swelling around tumors in the spine, brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve pain or other symptoms caused by the pressing tumor.

Another way this drug works is by altering the body's normal immune system responses. If you are a consumer or patient please visit this version. Prednisone is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Prednisone is a white to practically white, odorless, crystalline powder. It is very slightly soluble in water; slightly soluble in alcohol, in chloroform, in dioxane, and in methanol.

The chemical name for prednisone is pregna-1, 4-diene-3, 11, trione, 17, dihydroxy-. Prednisone Tablets, USP are available in three strengths: 5 mg, 10 mg, and 20 mg. Naturally occurring glucocorticoids hydrocortisone and cortisone , which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli. Primary or secondary adrenocortical insufficiency hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance.

As adjunctive therapy for short-term administration to tide the patient over an acute episode or exacerbation in:. Psoriatic arthritis Rheumatoid arthritis, including juvenile rheumatoid arthritis selected cases may require low-dose maintenance therapy Ankylosing spondylitis Acute and subacute bursitis Acute nonspecific tenosynovitis Acute gouty arthritis Post-traumatic osteoarthritis Synovitis of osteoarthritis Epicondylitis.

Systemic lupus erythematosus Systemic derznatomyositis polymyositis Acute rheumatic carditis. Pemphigus Bullous dermatitis herpetiformis Severe erythema multiforme Stevens-Johnson syndrome Exfoliative dermatitis Mycosis fungoides Severe psoriasis Severe seborrheic dermatitis. Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:.

Seasonal or perennial allergic rhinitis Bronchial asthma Contact dermatitis Atopic dermatitis Serum sickness Drug hypersensitivity reactions. Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:. Allergic corneal marginal ulcers Herpes zoster ophthalmicus Anterior segment inflammation Diffuse posterior uveitis and choroiditis Sympathetic ophthalmia Allergic conjunctivitis Keratitis Chorioretinitis Optic neuritis Iritis and iridocyclitis.

Aspiration pneumonitis. Idiopathic thrombocytopenic purpura in adults Secondary thrombocytopenia in adults Acquired autoimmune hemolytic anemia Erythroblastopenia RBC anemia Congenital erythroid hypoplastic anemia. To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus. Tuberculous meningitis with subarachnoid block or, impending block when used concurrently with appropriate antituberculous chemotherapy Trichinosis with neurologic or myocardial involvement.

In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated. Corticosteroids may mask some signs of infection, and new infections may appear during their use.

There may be decreased resistance and inability to localize infection when corticosteroids are used. Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

Usage in pregnancy: Since adequate human reproduction studies have not been done with corticosteroids, the use of these drugs in pregnancy, nursing mothers or women of childbearing potential requires that the possible benefits of the drug be weighed against the potential hazards to the mother and embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy, should be carefully observed for signs of hypoadrenalism.

Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.

These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. While on corticosteroid therapy patients should not be vaccinated against smallpox. Other immunization procedures should not be undertaken in patients who are on corticosteroids, especially on high dose, because of possible hazards of neurological complications and a lack of antibody response.

The use of Prednisone Tablets, USP in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate anti-tuberculous regimen. FDA label information for this drug is available at DailyMed. Prednisone is approved to be used to reduce inflammation and suppress lower the body's immune response. It is used with other drugs to treat the following types of cancer :.

Prednisone is also used alone or with other drugs to prevent or treat the following conditions related to cancer:. Prednisone is also used alone or with other drugs to treat many other diseases and conditions.

The drug continues to be studied in the treatment of many types of cancer and other conditions. MedlinePlus Information on MedlinePlus Information for Prednisone - A lay language summary of important information about this drug that may include the following:.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

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